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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">boolt</journal-id><journal-title-group><journal-title xml:lang="ru">Бюллетень Государственного Никитского ботанического сада</journal-title><trans-title-group xml:lang="en"><trans-title>Bulletin of the State Nikitsky Botanical Gardens</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0513-1634</issn><publisher><publisher-name>Federal State Funded Institution of Science “The Labour Red Banner Order Nikitsky Botanical Gardens – National scientific Center of the RAS”</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">boolt-1059</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЗАЩИТА РАСТЕНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PLANT PROTECTION</subject></subj-group></article-categories><title-group><article-title>ЭФФЕКТИВНОСТЬ ИННОВАЦИОННОГО ОЛИГОНУКЛЕОТИДНОГО ИНСЕКТИЦИДА КОККУС-11 В БОРЬБЕ С COCCUS HESPERIDUM L.</article-title><trans-title-group xml:lang="en"><trans-title>Efficiency of the innovative oligonucleotide insecticide СOССUS-11 in the  control of Coccus hesperidum L.</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гальчинский</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gal’chinsky</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никита Витальевич Гальчинский</p><p>295007, Республика Крым, г. Симферополь, проспект Академика Вернадского, 4</p></bio><email xlink:type="simple">pcr.product@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГАОУ ВО «КФУ им. В.И. Вернадского»<country>Россия</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>21</day><month>01</month><year>2026</year></pub-date><volume>1</volume><issue>157</issue><fpage>132</fpage><lpage>141</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гальчинский Н.В., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Гальчинский Н.В.</copyright-holder><copyright-holder xml:lang="en">Gal’chinsky N.V.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://boolt.elpub.ru/jour/article/view/1059">https://boolt.elpub.ru/jour/article/view/1059</self-uri><abstract><p>Насекомые значительно превосходят все виды живых организмов по численности видов и общей биомассе, являясь одним из наиболее заметных консументов растений на планете. Для сохранения урожая одной из основных задач в сельском хозяйстве всегда была необходимость контроля и сокращения численности насекомых-вредителей. Современное использование химических инсектицидов приводит к накоплению ксенобиотиков в природе и сокращению биоразнообразия, включая насекомых. Устойчивое развитие человеческого общества невозможно без полезных насекомых, поэтому борьба с вредителями должна быть эффективной и избирательной. В данной статье показано, что применение контактного олигонуклеотидного инсектицида КОККУС-11 в концентрации 100 нг/мкл в отношении личинок Coccus hesperidum L. привело к гибели 95,59±1,63% в течение 12 суток. Природные олигонуклеотидные инсектициды демонстрируют новый метод борьбы с насекомыми-вредителями, который эффективен и безопасен для окружающей среды.</p></abstract><trans-abstract xml:lang="en"><p>Insects significantly exceed all types of living organisms in terms of species diversity and total biomass, being one of the most prominent consumers of plants on the planet. To preserve crops, one of the main tasks in agriculture has always been the need to control and reduce the number of pest insects. The modern use of chemical insecticides leads to the accumulation of xenobiotics in nature and a reduction in biodiversity, including insects. Sustainable development of human society is impossible without beneficial insects, so pest control must be effective and selective. This article shows that the use of the contact oligonucleotide insecticide COCCUS-11 at a concentration of 100 ng/µl against the larvae of Coccus hesperidum L. resulted in the death of 95.59 ± 1.63 % within 12 days. Natural oligonucleotide insecticides demonstrate a new method of pest control that is effective and safe for the environment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ДНК-инсектициды</kwd><kwd>КВАДб</kwd><kwd>контактно вводимая антисмысловая ДНК</kwd><kwd>мягкая ложнощитовка</kwd><kwd>смолосемянник обыкновенный</kwd><kwd>Coccus hesperidum L.</kwd><kwd>Pittosporum tobira (Thunb.) W.T. Aiton</kwd></kwd-group><kwd-group xml:lang="en"><kwd>DNA insecticides</kwd><kwd>CUADb</kwd><kwd>contact unmodified antisense DNA</kwd><kwd>brown soft scale</kwd><kwd>Japanese cheesewood</kwd><kwd>Coccus hesperidum L.</kwd><kwd>Pittosporum tobira (Thunb.) W.T. 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